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Interspecies Variability in Antibody-Dependent Cellular Cytotoxicity (ADCC)¹

From the Department of Microbiology and Immunology, School of Medicine, University of California, Los Angeles, California 90024

Abstract

Lymphoid effector cells and antisera from several species were evaluated in allogeneic or xenogeneic test systems for their ability to mediate the cytolysis of radiochromium-labeled target cells, antibody-dependent cellular cytotoxicity (ADCC). Interspecies variation was observed at both the effector cell and antibody level. Species-dependent variability in either the structure or function of the effector cell receptor, the structure or function of the antibody molecule binding site for the effector cell, or a combination of these factors may be reflected in interspecies variability in ADCC activity.

Footnotes

¹ This study was supported by Grant CA 12800 from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland, and a grant from the California Institute of Cancer Research.