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Immunologic Functions of Isolated Human Lymphocyte Subpopulations

II. Antigen Triggering of T and B Cells in Vitro¹

From the Division of Tumor Immunology, Children's Cancer Research Foundation, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Abstract

Soluble and cell surface antigen-induced triggering of highly purified human T and B cells was studied measuring ³H-thymidine incorporation in vitro. T cells but not B cells from antigen-sensitive donors responded to specific soluble antigen challenge. Nonsensitized cells failed to respond. The addition of sensitized T cells to autologous B cells did not induce B cells to proliferate in response to soluble antigen. In one-way mixed leukocyte cultures, T cells but not B cells incorporated ³H-thymidine in response in allogeneic mitomycin-treated targets. In contrast, both T and B target cells were capable of inducing proliferation of allogeneic T cells.

Footnotes

¹ This work was supported in part by Grants AI-12069 and CA-05167 from the National Institutes of Health.

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