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Basophilic Leukocytes in Delayed Hypersensitivity Reactions

From the Department of Pathology, Royal College of Surgeons of England, Lincoln's Inn Fields, London WC2A 3PN, and Institute of Dermatology, St. John's Hospital for Diseases of the Skin, Homerton Grove, London E9 6BX

Abstract

In guinea pigs, basophilic leukocytes constitute a high proportion of the cells infiltrating allergic contact, Jones-Mote and tuberculin-like reactions, when elicited 1 week after sensitization with 2,4 dinitrofluorobenzene, ovalbumin (OA) in Freund's incomplete adjuvant (FIA) and OA in Freund's complete adjuvant (FCA), respectively. When animals are pretreated with one dose (300 mg/kg) of cyclophosphamide, 3 days before sensitization, allergic contact and Jones-Mote reactions, elicited 7 days after sensitization, are increased in intensity and induration and prolonged, whereas the tuberculin-like reactions are somewhat reduced in intensity. The percentages of basophils infiltrating all these altered reactions are markedly reduced. Thus, delayed-in-onset skin reactions may occur in guinea pigs immunized with proteins in FIA or FCA or in contact-sensitized animals in the presence or absence of basophils.

Footnotes

¹ National (U.S.A.) Dermatology Foundation Fellow.

² Address reprint requests to: Prof. J. L. Turk, Royal College of Surgeons of England, Lincoln's Inn Fields, London WC2A 3PN, U.K.