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Migration Inhibition Test in Leukocytes from Patients Allergic to Penicillin

From the Departamento de Ecología Humana, Facultad de Medicina, U.N.A.M. and Servicio de Alergia e Inmunología Clínica, Hospital General del Centro Médico, I.M.S.S.

Abstract

Leukocytes from patients with an allergy to penicillin failed to migrate when exposed in vitro to penicillin coupled to human -globulin. On the other hand, leukocytes from nonallergic individuals showed no inhibition of migration when exposed to the same antigen.

The sera from the allergic patients were able to sensitize leukocytes obtained from nonallergic individuals. Inhibition of migration of these sensitized leukocytes is produced upon exposure to penicillin--globulin. However, a reversal of the latter inhibition of leukocyte migration was observed when the allergic sera were previously treated with penicillin G alone. The allergic sera able to sensitize leukocytes contained antibodies to penicillin. These antibodies were demonstrated by their ability to neutralize bacteriophage T4 coated with penicillin.