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Generation of Non-Complement-Fixing, Blocking Factors by Lysosomal Extract Treatment of Cytotoxic Anti-Tumor Antibodies¹

From the Clinical Immunology Section and Department of Medicine, Veterans Administration Hospital and University of California, San Francisco, San Francisco, California, and the Department of Microbiology, Tel Aviv University, Tel Aviv, Israel

Abstract

Alloantibodies against EL-4 lymphoma and P-815 mastocytoma were raised by immunization of DBA/2 and C57BL/6 mice, respectively. Such antisera were capable of mediating complement-dependent cytotoxicity and of blocking specific killing by alloimmune lymphocytes. Treatment with lysosomal enzymes derived from the tumor decreased the ability of these alloantibodies to mediate complement-dependent cytotoxicity but left intact their blocking activity. Such degradation, if it were to occur, in vivo could contribute to enhanced tumor growth.

Footnotes

¹ This work was supported in part by research funds from the Veterans Administration and by Contract NO1-CB-43858 from the National Cancer Institute.

² This work was performed while Dr. Witz was on sabbatical at the University of California, San Francisco.