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The Journal of Immunology, 1974, 113: 925-933.
Copyright © 1974 by The American Association of Immunologists, Inc.
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Enhancement of the Humoral Response of T Cell-Depleted Murine Spleens by a Factor Derived from Human Monocytes in Vitro

D. D. Wood and S. L. Gaul

From the Merck Institute for Therapeutic Research, Rahway, New Jersey 07065

Abstract

The humoral response of thymus-derived (T) cell-depleted murine spleen cultures was stimulated by the addition of human leukocytes. The stimulatory human cell type was found to be adherent and phagocytic suggesting that it is the monocyte. The stimulation appears to be mediated by a factor released by the adherent cells into the culture medium.






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