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The Use of Allogeneic T Lymphocytes and Bacterial Lipopolysaccharide to Induce Immune Responses to Monovalent Haptens in Vitro¹

From The Salk Institute for Biological Studies, Post Office Box 1809, San Diego, California 92112

Abstract

Immune responses to monovalent haptens were stimulated in mouse spleen cultures either by the addition of bacterial lipopolysaccharide (LPS) or by T cells reactive against the alloantigens on precursor antibody-forming cells (P-AFC). These findings suggest that P-AFC require two independently delivered signals for the induction of antibody synthesis. One signal is delivered via the interaction of hapten with surface immunoglobulin receptors. A second signal is delivered either by LPS or via the interaction of a T cell with cell surface determinants on P-AFC.

Footnotes

¹ This work was supported by National Institutes of Health Research Fellowship 1705 TWO 1795-01 and a Fellowship of Deutsche Forschungsgemeinschaft to Ekkhart Trenkner, and Public Health Service Grants AI05875 and AI00430 (Training Grant) from the National Institute of Allergy and Infectious Diseases to Melvin Cohn.