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Potentiation of Helper T Cell Function in IgE Antibody Responses by Bacterial Lipolysaccharide (LPS)¹

From The Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Abstract

The effects of bacterial lipopolysaccharide (LPS) on hapten-specific IgG and IgE responses to DNP-protein conjugates has been analyzed in an adoptive transfer system in mice. Administration of LPS to irradiated recipients of DNP-Ascarisprimed spleen cells at the time of secondary challenge enhanced the responses in both antibody classes to the original immunizing antigen demonstrating clearly that the mechanisms controlling both IgE and IgG antibody production are subject to the adjuvant influence of LPS. Responses in the IgE class appear to be more sensitive to enhancing effects of lower doses of LPS than is true of IgG responses. That the adjuvant effect of LPS is exerted on helper T cell function in this system has been directly shown in these studies by the substantial enhancement of development of carrier-specific helper function obtained by administering LPS at the time of carrier immunization. Whether this adjuvant effect reflects direct activation of T cells by LPS or, rather, an indirect effect mediated by macrophages and/or biologically active factors remains to be solved.

Footnotes

¹ This investigation was supported by Grant AI-10630 from the National Institutes of Health, United States Public Health Service.