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Evidence for the T Cell Specificity of Sodium Periodate-Induced Lymphocyte Blastogenesis¹

From the Division of Biochemistry, The University of Texas Medical Branch, Galveston, Texas 77550

Abstract

Sodium periodate (NaIO₄) treatment of lymphocytes can induce blastogenic transformation similar to that caused by plant lectins. In this study we have found that spleen cells from congenitally athymic (nude) mice do not undergo blastogenesis when treated with NaIO₄, in contrast to the extensive blastogenesis observed with NaIO₄-treated spleen cells from normal littermates (heterozygous for the nude gene) and CBA/J mice. Prior treatment with NaIO₄ only partially reduced the capacity of nude spleen cells to respond to a B cell mitogen. Lack of stimulation of nude spleen cells treated with NaIO₄ indicates the possible T cell specificity of this mitogenic agent.

Footnotes

¹ This investigation was aided by grants from the National Cancer Institute (CA15419 and CA14108) and the John Hartford Foundation, Inc.

² Cancer Research Laboratory, St. Joseph Hospital, Houston, Texas 77002.