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Abrogation of Resistance to Bone Marrow Grafts by Silica Particles

Prevention of the Silica Effect by the Macrophage Stabilizer Poly-2-Vinylpyridine N-Oxide¹

From the Department of Pathology, School of Medicine, State University of New York at Buffalo, Buffalo, New York 14214

Abstract

An attempt was made to assess the role of macrophages in resistance of irradiated mice to parental-strain and allogeneic bone marrow grafts. 1.25 to 5 mg of silica particles injected i.v. (5 µ average size) are specifically toxic to macrophages and resulted in prompt abrogation or reduction of hybrid and allogeneic resistance. The silica was equally effective when given within 2 days before or after transplantation of bone marrow cells. The effectiveness decreased with increasing intervals, but foreign marrow cells could be rescued from rejection as long as 3 days after grafting. The macrophage stabilizer poly-2-vinylpyridine N-oxide injected subcutaneously (150 mg/kg) 1 day before silica entirely prevented the suppression of hybrid resistance. It was concluded that macrophages, or a subpopulation thereof, could be the effectors of hemopoietic graft rejection by irradiated mice. The immunogenetic specificity of these allograft reactions and the suppressive effects of anti-lymphocyte agents suggest, however, that also lymphoid cells participate in this process.

Footnotes

¹ This research was supported in part by United States Public Health Service Grants AM-13969, CA-12844, and CA-02357, National Institutes of Health, Bethesda, Maryland.

² Present address: Division of Experimental Biology, Baylor College of Medicine, Texas Medical Center, Houston, Texas 77025.

³ To whom reprint requests should be addressed.

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