HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chisari, F. V. Articles by Northrup, R. S. Search for Related Content PubMed Articles by Chisari, F. V. Articles by Northrup, R. S.

Pathophysiologic Effects of Lethal and Immunoregulatory Doses of Cholera Enterotoxin in the Mouse

From the Laboratories of Pathology and Bacterial Products, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Cholera enterotoxin (CE) can kill mice, produce severe thymic cortical atrophy and depletion of lymphoid cells from splenic red pulp. Furthermore, lethal doses can decrease the viability of spleen cells and thymocytes in vitro and produce severe hypercalcemia which probably is responsible for the lethal effect. However, a sublethal dose known to have the capacity to modulate the immune response exerts a distinct stimulatory effect on cells in the splenic red pulp whereas cortical thymocytes are destroyed even at this lower dose. A lesser degree of serum calcium elevation is also produced. The differential susceptibility of thymus and bone marrow-derived cells to CE and the role which the adenyl cyclase-cyclic AMP system plays in these effects is discussed.

Footnotes

¹ Current address: Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

² Current address: University of Hawaii Postgraduate Medical Education Program for Okinawa, Okinawa Central Hospital, Gushikawa City, Okinawa, Japan.

This article has been cited by other articles:

				R. Weltzin, B. Guy, W. D. Thomas Jr., P. J. Giannasca, and T. P. Monath Parenteral Adjuvant Activities of Escherichia coli Heat-Labile Toxin and Its B Subunit for Immunization of Mice against Gastric Helicobacter pylori Infection Infect. Immun., May 1, 2000; 68(5): 2775 - 2782. [Abstract] [Full Text] [PDF]