HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Chisari, F. V. Articles by Chen, L. C. Search for Related Content PubMed Articles by Chisari, F. V. Articles by Chen, L. C.

The Modulating Effect of Cholera Enterotoxin on the Immune Response

From the Laboratories of Pathology and Bacterial Products, Division of Biologics Standards, and National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Cholera enterotoxin (CE) is a potent adjuvant when administered simultaneously with sheep red blood cells (SRBC) and an immunosuppressant when given 12 hr before or after the antigen. Antigen clearance is not modified, but splenic adenyl cyclase activity is significantly enhanced reaching peak levels within 12 hr. Theophylline enhances the modest adjuvant effect of 0.01 µg of CE and inhibits the pronounced adjuvant effect of 0.05 µg. The relationship between adenyl cyclase stimulation and modulation of the immune response is discussed.

Footnotes

¹ Current address: Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

² Current address: University of Hawaii Postgraduate Medical Education Program for Okinawa, Okinawa Central Hospital, Gushikawa City, Okinawa, Japan.

³ Current address: c/o Ford Foundation, Dacca, Bangladesh.