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Letters to the Editor

Sir: Rabinowitz and her colleagues (1) recently discussed the serologic code models (i.e., "simple-complex" or "complex-simple" as outlined by Hirschfeld (2)) with respect to the action of allogenic anti- and xenogenic anti-mouse or anti-rat brain sera on thymocytes and brain matter. Even if these authors emphasized that they did not wish to commit themselves, on the basis of blocking experiments resembling those we previously have published (3, 4), they favored the "simple-complex" interpretation in this connection for simplicity's sake. However, there are experimental data that hardly reconcile with this interpretation. Thus it has been shown by absorption analyses that anti-CBA brain sera elicited in rabbits contain at least two categories of thymocyte-specific antibodies; one of them reacts with determinants present on thymocytes and brain of all mouse strains tested so far, inclusive of those bearing the _AKR marker, the other binds to antigenic structures existing on mouse as well as on rat thymocytes and brain (3, 5).