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The Effect of Estrogen on the Incorporation of ³H-Thymidine by PHA-Stimulated Human Peripheral Blood Lymphocytes

Immunobiology Section and the Center for the Study of Prostatic Diseases, Division of Urology, Cook County Hospital and Graduate School of Medicine; The Hektoen Institute for Medical Research; Mount Sinai Hospital Medical Center; and the Departments of Microbiology and Urology, the Chicago Medical School/University of Health Sciences, Chicago, Illinois

Abstract

The incorporation of ³H-thymidine by PHA-stimulated human peripheral blood lymphocytes from healthy adult males was significantly (p 0.002) suppressed in the presence of diethylstilbestrol diphosphate. The observed suppression of blastogenesis in the presence of exogenous estrogen suggests that the palliative effects of estrogenic therapy in the clinical treatment of patients with hormonally-responsive tumors may be countered by its adverse effect of the host's cell-mediated immunologic responsiveness.

Footnotes

¹ Address correspondence to Dr. R. J. Ablin, Immunobiology Section, Division of Urology, Cook County Hospital, Chicago, Illinois 60612.