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Immunoglobulin Expression of Cells from Human Lymphoblastoid Lines

II. Interrelationship Among Surface, Cellular, and Secreted Immunoglobulins^1,2,

Division of Human Genetics, Department of Medicine, Cornell University Medical College, New York, New York 10021

Abstract

The interrelationship among surface, cellular, and secreted Ig in eight human lymphoblastoid lines was studied. Qualitative and quantitative data for cellular and secreted Ig paralleled each other. No "secretory block," i.e., failure of an individual line to secrete cell-associated Ig, was observed. In contrast to the close relationship observed between cellular and secreted Ig, two lines showed a dissociation between the expression of surface, and that of cellular/secreted Ig.

Previous data have raised the possibility of similarities between lymphoblastoid cells and immature B lymphocytes. The different patterns of Ig expression with respect to surface, cellular, and secreted Ig were consistent with a theoretical model for development of B lymphocytes. The significance of these observations was discussed.

Footnotes

¹ This work was supported in part by United States Public Health Service Grants AI 09239, AM 20122, and AM 11796. P. K. Lin is a post-doctoral trainee (United States Public Health Service Training Grant GM 01918).

² This work was presented in part at the National Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, New Jersey, April 1973.