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Distribution of Isotypic and Allotypic Human IgG Antigens in Non-Human Primates

Institute of Immunology and Rheumatology, Rikshospitalet, Oslo 1, Norway

Abstract

The occurrence of a range of human isotypic and allotypic antigens in various non-human primate species was investigated. Most of the antigens were found only among the Hominoidea. However, certain isotypic antigens of IgG1 and IgG4 and allotypic antigens of IgG1 (Gm(f) and Gm(z)) and IgG3 (Gm(b⁰) and Gm(c⁵)) were found in Old World monkeys as well. IgG2 antigens were found within the Pongidae only. The subclass antigens were generally not more widely distributed than the allotypes. Several species had remarkably high serum concentrations of Gm(b⁰) and Gm(c⁵). In chimpanzees Gm(b⁰) may occur in several subclasses and "non b⁰" as an allotype within one minor subclass, thus reversing the relationship observed in man between these two antigens. The sheer multitude of iso- and allotypic antigens found makes the existence of subclasses likely in several species. Immunosorbent studies, however, provided strong evidence for the existence in chimpanzees of at least two IgG populations corresponding to subclasses.