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The Journal of Immunology, 1974, 113: 501-506.
Copyright © 1974 by The American Association of Immunologists, Inc.
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DNP-Antigens Activate the Alternate Pathway of the Complement System1

Wolfgang König, Dieter Bitter-Suermann, Manfred Dierich, Michael Limbert, Hans-Ulrich Schorlemmer and Ulrich Hadding

Institut für Medizinische Mikrobiologie, Johannes-Gutenberg-Universität, Mainz, Germany

Abstract

Dinitrophenyl-human serum albumin (DNP-HSA) preparations activate C3 via the alternate pathway of the complement system depending on the grade of DNP substitution. This potency seems to be due to the polyanionic character of DNP-HSA and thus resembles in its behavior other polyanions.

Footnotes

1 This work was supported by grants of the Sonderforschungsbereich 107 (Immunology) at Mainz.






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