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The Journal of Immunology, 1974, 113: 496-500.
Copyright © 1974 by The American Association of Immunologists, Inc.
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The Cutaneous Basophil Response to Mitogens1

Miguel J. Stadecker2 and Sidney Leskowitz

Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111

Abstract

Basophil-rich skin reactions have been elicited in normal guinea pigs with local injections of phytohemagglutinin, concanavalin A, and pokeweed mitogen. Escherichia coli lipopolysaccharide, a B cell mitogen, had no such effect.

These results suggest that T cells may mediate such reactions by releasing a factor chemotactic for basophils.

Footnotes

1 This work was supported in part by United States Public Health Service Grant AI-10895.

2 This work was performed in partial fulfillment of the requirements for the Ph.D. degree, Tufts University.






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