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Induction of Anti-DNP Antibodies: Suppressive Effect of Circulating Anti-Iodiotypic Antibodies to Mouse Myeloma Protein MOPC 315¹

From The Department of Pathology, University of Geneva Faculté of Medicine, Geneva, and the Basel Institute for Immunology, Basel, Switzerland

Abstract

Immunization of BALB/c mice with MOPC 315, and mouse myeloma protein with anti-DNP activity, induces the formation of anti-315 idiotypic antibodies. The idiotypic-anti-idiotypic reaction is partially inhibited by BALB/c serum containing anti-DNP antibodies, indicating an idiotypic similarity between 315 and at least some of the anti-DNP antibodies. Hemagglutination data indicate that a high proportion of induced BALB/c anti-DNP antibodies contain L chains of type. Mice with circulating anti-315 idiotypic antibodies show, after immunization with DNP-KLH, a depressed anti-DNP antibody response.

Footnotes

¹ This work was supported by Grant No 3.408.70 of the Fonds National Suisse de la Recherche Scientifique.

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