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Further Studies on the Inhibition of Allergic Encephalomyelitis by L-Asparaginase¹

From the Wadley Institutes of Molecular Medicine, Dallas, Texas 75235, and New York Medical College, Bird S. Coler Hospital, Welfare Island, New York, New York 10017

Abstract

L-Asparaginase inhibited the hyperacute form of EAE in rats. The inhibition was inversely proportional to the intensity of the eliciting immunization. Passive transfer experiments proved that at least part of the inhibition was related to effects on the fully immunized lymphoid cells and its interaction with the neural target. The inhibition was caused by specific enzyme activity and not by endotoxin contamination or nonspecific stress.

Footnotes

¹ This work was supported in part by Grant 536C12 from the National Multiple Sclerosis Society and Medical Research Inc. of Dallas.