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The Occurrence of Shared Idiotypic Specificity among the Goat Antibodies That Distinguish Human Hemoglobin S from A₁¹

From the Departments of Medicine and Biochemistry, State University of New York at Buffalo, School of Medicine, Veteran's Hospital, Buffalo, New York 14215

Abstract

Rabbits have been immunized with the goat antibody population(s) that distinguishes human hemoglobin S (sickle) from A₁. After appropriate absorption these rabbit sera bind only the S-specific antibody and not the antibodies that cross-react with hemoglobin A₁. S-specific antibody from three individual outbred goats gives reactions of complete immunologic identity in double diffusion reactions in agar with rabbit sera made specific for the antibody that distinguishes hemoglobin S from A₁. Quantitative studies of these reactions by radioimmunoassay support the notion that the idiotypic determinants from these three goats have similar antigenic reactivity.

Footnotes

¹ This work was supported by designated research funds from the Veteran's Administration and Grant AM10428 from the United States Public Health Service.

² In partial fulfillment of the degree of doctor of philosophy to the graduate school of SUNY at Buffalo. Supported by predoctoral fellowship United States Public Health Service GM46140.

³ Please send reprint requests to: Robert D. Schreiber, Department of Experimental Pathology, Scripps Clinic and Research Foundation, 476 Prospect Street, La Jolla, California 92037.