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Demonstration of Molecular Individuality of HL-A Antigens¹

From the Department of Microbiology and Immunology, University of California at Los Angeles, School of Medicine, Los Angeles, California 90024

Abstract

Partially purified HL-A antigens, isolated by papain digestion from membranes of cultured lymphocytes, were subjected to a combination of immunoabsorbance and polyacrylamide gel electrophoresis. With four alloantisera, specific for the HL-A antigens characteristic of the cell line, each antigen could be completely separated from the other three. The results prove that the four HL-A antigens determined by a single genotype are present on four distinct molecular species.

Footnotes

¹ This investigation was supported by Grant CA 12800 from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

² Recipient of a Postdoctoral Fellowship from the American Cancer Society.