HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Plaut, A. G. Articles by Tomasi, T. B. Search for Related Content PubMed Articles by Plaut, A. G. Articles by Tomasi, T. B., Jr.

Isolation of an Enzyme from Streptococcus Sanguis Which Specifically Cleaves IgA¹

From the Department of Medicine, Tufts-New England Medical Center Hospital, Boston, Massachusetts; Department of Medicine and Dentistry, State University of New York at Buffalo; and Department of Immunology, Mayo Medical School, Rochester, Minnesota

Abstract

IgA protease, a metal-dependent endopeptidase elaborated by bacteria normally found in the human oral cavity and intestinal tract, can be isolated in good yield from culture filtrates of Streptococcus sanguis. The enzyme has pronounced specificity for secretory and serum IgA, which it cleaves to form Fc and Fab fragments.

Footnotes

¹ This work was supported by National Institutes of Health Grants AM AI 16607, DE 02814, and AM 10419, Contract 17-74-C-4022 from the U. S. Army Medical Research and Development Command, and Research Career Development Award AI 70420 (to Dr. Plaut).

This article has been cited by other articles:

				J. Reinholdt and M. Kilian Interference of IgA Protease with the Effect of Secretory IgA on Adherence of Oral Streptococci to Saliva-coated Hydroxyapatite Journal of Dental Research, February 1, 1987; 66(2): 492 - 497. [Abstract] [PDF]

				M. A. Taubman and D. J. Smith Immune Components in Dental Plaque Journal of Dental Research, April 1, 1976; 55(3_suppl): C153 - C162. [PDF]