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Regulation of T Lymphocyte Function by Immunoregulatory Alphaglobulin (IRA)¹

From the Department of Surgery, Biochemistry, and Medicine, Boston University Medical Center, Boston, Massachusetts 02118

Abstract

Immunoregulatory alphaglobulin, IRA, has been shown to suppress T cell-dependent immune responses. The present studies were to determine the effect of IRA on B cell-mediated immune responses. IRA-protein, and a more purified species, IRA peptide were shown to inhibit the T cell-mediated responses of spontaneous rosette formation between human peripheral lymphocytes and sheep red blood cells (SRBC) and the plaque-forming cell response in mice injected with SRBC. The same IRA preparations were ineffective in suppressing rosette formation between human peripheral lymphocytes and EAC-SRBC and the plaque-forming cell response to Escherichia coli lipopolysaccharide, both of which are B cell-mediated, T cell-independent immune responses. Therefore, we believe that IRA is effective in nonspecific suppression of only immune responses dependent on T cell function.

Footnotes

¹ This study was supported by Grants CA-12209, AM-10824, GM-10374, and 5F02DE44743 from the Public Health Service, National Institutes of Health.