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Alteration of Rabbit PCA Reaction by Drugs Known to Influence Intracellular Cyclic AMP¹

From the School of Medicine, University of California, San Diego, University Hospital Department of Medicine, San Diego, California 92103

Abstract

Pharmacologic agents which are known to modulate the immunologic release of mediators of anaphylaxis in vitro were analyzed for their effect on the rabbit passive cutaneous anaphylactic (PCA) reaction. Intravenous propranolol increased the diameter of the skin lesions. Isoproterenol in combination with aminophylline inhibited the PCA reaction. Prostaglandin (PGE₁) and histamine phosphate caused marked decrease in diameter of skin blueing. These studies support the hypothesis that control of mediator release may be modulated in vivo by drugs which are known to influence intracellular concentrations of cAMP. Because of the complex pharmacologic events which accompany these agents when introduced in vivo, the results are interpreted to include mechanisms in addition to the cAMP system.

Footnotes

¹ This work was done under the sponsorship of the Commission on Parasitic Diseases of the Armed Forces Epidemiological Board and was supported (in part) by the United States Army Medical Research and Development Command under Research Conract DADA 17-71-C-1002.

² Supported (in part) by funds from the Public Health Service: 5 TO1 HL05880 (T.C.K.)

³ Address correspondence and reprint requests to: Nathan J. Zvaifler, M.D., Department of Medicine, University Hospital, 225 West Dickinson Street, San Diego, California 92103.