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IgM-Forming Cells as the Immediate Precursor of IgA-Producing Cells during Ontogeny of the Immunoglobulin-Producing System of the Chicken¹

From the Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana 70112

Abstract

Chickens bursetomized at hatch and treated with either anti- or anti-µ had depressed serum levels of both IgM and IgA, whereas IgY production was unaffected. Chickens bursectomized at hatch and treated with anti- + anti-µ combined had more severely depressed levels of serum IgM and IgA than bursectomized chickens treated with either antibody alone. The suppressive effects of anti-µ on IgA, anti- on IgM, and the the additive suppressive effect of combined antibody treatment on both IgM and IgA suggest that IgA-producing cells are derived from IgM-forming precursor cells through a doubly-producing intermediate. The lack of suppressive effect on IgY production in birds having severe depression of IgM and IgA indicates that few if any IgY-forming cells serve as precursors for IgA-producing cells.

Footnotes

¹ This work was supported in part by National Science Foundation Grant GB-31001, a grant from the John A. Hartford Foundation, Inc., and a grant from the National Tuberculosis and Respiratory Disease Association.

² Present address: Tulane University, Delta Regional Primate Research Center, Covington, Louisiana 70433.

³ Present address: Department of Microbiology, University of Oregon Medical School, Portland, Oregon 97201.