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The Relationship between PF/DIL and Activated Human Hageman Factor¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Permeability factor of dilution (PF/dil) activity, prepared by dilution of human plasma in contact with glass, was removed by insolubilized antibody to human Hageman factor. Insolubilized normal globulin or antibodies to prekallikrein failed to remove PF/dil activity. Dilutions of Fletcher trait plasma (a prekallikrein deficiency) failed to generate PF/dil activity but addition of purified prekallikrein reconstituted the capacity to generate PF/dil activity. These data support the conclusion that PF/dil and activated Hageman factor are identical and that generation of PF/dil (HFa) requires fluid phase activation with kallikrein.

Footnotes

¹ This is publication 771 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, 476 Prospect Street, La Jolla, California 92037. Support was provided by the United States Public Health Service Grant AI-07007, the Council for Tobacco Research, and the American Heart Association.