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Sites of Localization and Synthesis of Ss Protein in Mice

Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218

Abstract

Ss, a serum protein whose structure and level in serum are determined by genes of the mouse H-2 complex, has been localized to a variety of cell types, using immunofluorescence and radiolabel techniques. Peritoneal macrophages and liver parenchymal cells appear to synthesize Ss for export to serum. These cells stain in the cytoplasm for Ss and release labeled Ss into the medium of cultures fed ¹⁴C amino acids. Other cultured cells, fibroblasts of Ss high strains, bear the protein only on their membranes. The membrane-bound form of Ss has at least one antigenic determinant masked; this determinant is exposed when membrane-as-sociated Ss is released into culture medium. At least in some cells then, Ss, like the other products of H-2 region genes, is membrane associated.

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