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Ontogeny of Immunoglobulin-Bearing Lymphocytes and DNP-Specific Antigen-Binding Cells in Guinea Pigs

Laboratory of Immunology and Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Departments of Pathology and Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110

Abstract

The ontogeny of immunoglobulin (Ig)-bearing and antigen-binding lymphocytes in guinea pigs was examined. At 54 days of gestation, fetal spleen contained adult percentages of IgM-bearing lymphocytes, but few which bore either IgG1 or IgG2, immunoglobulin. By term, the fraction of cells bearing each of the major Ig classes had reached, or was approaching, adult levels. In addition, the appearance of Ig-bearing cells with receptors specific for 2,4-dinitrophenyl (DNP) groups was determined. By 50 days of gestation considerable numbers of these cells were found. Virtually all these cells possessed surface Ig of the µ class. Only at term did IgG2-bearing DNP-binding cells appear. In the adult guinea pig, the majority of DNP-specific lymphocytes possess surface Ig of the IgG2 class.

Footnotes

¹ Departments of Pathology and Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110. Supported in part by the following Tobacco Companies: Brown & Williamson Tobacco Corporation; Larus & Brother Company, Inc.; Liggett & Myers, Incorporated; Lorillard, a Division of Loew's Theatres, Inc.; Philip Morris, Inc.; R. J. Reynolds Tobacco Company; United States Tobacco Company; and Tobacco Associates, Inc.

² Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014.

³ Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014.

⁴ Supported in part by Grant GM02016.