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Fluorescent Antibody Responses to Chlamydial Infection in Patients with Lymphogranuloma Venereum and Urethritis¹

Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health, Education, and Welfare, Hamilton, Montana 59840, and the Naval Medical Research Institute, Bethesda, Maryland 20014

Abstract

Indirect immunofluorescence (the micro IF test) was used to study trachomainclusion conjunctivitis and lymphogranuloma venereum (LGV) serum antibody patterns in a venereal disease clinic population. Antibodies undifferentiated as to immunoglobulin class, but probably IgG, were detected in 80% of the study participants and titers were particularly high in LGV patients. Two kinds of antibody were observed. One was broadly reactive to all test antigens, and one was specifically directed toward strains of a particular antigenic type. Although most sera were broadly reactive, 40% also showed some type specificity. Specific antibody patterns in persons from whom chlamydiae were isolated usually corresponded to the immunotypes of isolates, and LGV reaction patterns were particularly associated with LGV patients. IgM antibodies were observed in 20% of the study participants. These were usually type specific and perhaps indicated current infection. The sensitive micro IF test is considered useful in the epidemiologic study of chlamydial infections of genital origin and can provide information about the nature of infecting strains.

Footnotes

¹ This study was supported in part by the Bureau of Medicine and Surgery, United States Department of the Navy, Research Task MF 12.524.009.1007B.

The opinions or assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Navy Department or the naval service at large.

² Deceased.