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Cellular Basis of Immunodepression in Mice with Plasmacytomas^1,2,

Veterans Administration Hospital and the Department of Pathology, New York University Medical School, New York, New York 10016 and the Department of Immunology, Hadassah Medical School, Hebrew University, Jerusalem, Israel

Abstract

The primary immune response to sheep red cells (SRC) in plasmacytoma (PC)-bearing mice is consistently depressed; the degree of depression is dependent on tumor size and the dose of antigen administered. Mice bearing the two PC which most severely depress the primary response also have an impaired ability to mount a secondary response to SRC. The primary response of PC-bearing mice to a thymus-independent antigen is also depressed, indicating that B cells are at least one of the cell populations adversely affected in tumor-bearing hosts. However, the B cell precursors of antibody-forming cells, antigen-binding cells, are found in normal quantities and appear capable of binding antigen. The data also suggest that the PC which cause the most severe immunodepression affect the maturation of the precursors of antibody-forming cells whereas those tumors that have a significant but less marked effect on antibody production do not appear to alter the process of differentiation in antigen-triggered cells.

Footnotes

¹ This work was supported by United States Public Health Service Grant AI-10057, American Cancer Society Institutional Grant In 14-0, and by a grant from the Veterans administration.

² Address reprint requests to Susan Zolla, Immunopathology Research Laboratory, V. A. Hospital, 408 First Avenue, New York 10010.

This article has been cited by other articles:

				P. Tanapatchaiyapong and S. Zolla Humoral Immunosuppressive Substance in Mice Bearing Plasmacytomas Science, November 22, 1974; 186(4165): 748 - 750. [Abstract] [PDF]