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The Ability of Chemotactic Factors to Induce Lysosomal Enzyme Release

II. The Mechanism of Release¹

Department of Pathology, University of Connecticut Health Center, Farmington Connecticut 06032

Abstract

Lysosomal enzyme release form rabbit peritoneal neutrophils induced by a bacterial chemotactic factor is temperature dependent; it requires external Ca²⁺ but not Mg²⁺ glycolysis as a source of metabolic energy and free sulfhydryl groups. The release is inhibitable by DFP under circumstances suggesting involvement of an activatable serine esterase. The release is enhanced by cytochalasin B. Low concentrations of colchicine and vinblastine enhance lysosomal enzyme release, as well as chemotaxis induced by the same chemotactic factor; higher concentrations inhibit.

Footnotes

¹ This is Communication 55 from the Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut. The work was supported by United States Public Health Service Grant AI 09648.

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