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The Proliferative Response of Bronchus-Associated Lymphoid Tissue after Local and Systemic Immunization¹

Department of Medicine, McMaster University, Hamilton, Ontario

Abstract

The rate of DNA synthesis has been examined in vitro in lymphocytes obtained from the bronchial mucosa (bronchus-associated lymphoid tissue or BALT), washings of the bronchial tract, and the spleen, in animals immunized locally and systemically with dinitrophenylated human -globulin. The spontaneous rate of DNA synthesis of lymphocytes isolated from the BALT or washings of the bronchial tract was considerably greater in animals immunized via the bronchial lumen when compared with systemically immunized animals. Bronchial washing lymphocytes and BALT responded selectively to local antigen, with a similar time course. Antibody-containing cells were detected in the spleen, particularly after footpad immunization, but could not be detected in either the BALT or the lamina propria of the bronchus after local or systemic immunization.

Footnotes

¹ This work was supported by the Medical Research Council and an Ontario Provincial Research Grant.