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In Vitro Demonstration of Complement-Dependent Cytotoxic Antibodies to Moloney Sarcoma Cells¹

Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195

Abstract

An in vitro microcytotoxicity assay was used to demonstrate complement-dependent cytotoxic antibodies to Moloney sarcoma virus-induced cells throughout the stages of tumor progression and regression in BALB/c mice. Complement-dependent cytotoxic antibodies were present in the sera of mice whose tumors were in the late stages of tumor growth, and most consistently in the sera of mice whose tumors had completely regressed (regressors). Regressor sera were strongly cytotoxic for at least 125 days after the onset of tumor regression. Preliminary evidence indicates that the complement-dependent cytotoxic antibody in regressor sera is a 7S immunoglobulin.

Footnotes

¹ This work was supported by Grants CA 10188 and CA 10189 from the National Institutes of Health, by Grant IC-56D from the American Cancer Society and by Contract NIH-NCI-71-2171 from the Virus Cancer Program of the National Cancer Institute, United States Public Health Service.

² This investigator was supported in part as a Graduate Research Trainee (Ca-5040), National Cancer Institute.