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Macrophage Receptors for Migration Inhibitory Factor (MIF), Migration Stimulatory Factor (MSF), and Agglutinating Factor¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

The action of macrophage migration inhibitory factor in fetal calf serum (FCS-MIF) was inhibited by l-fucose and by blood group substances and bovine submaxillary mucin, both of which contain l-fucose. FCS-MIF agglutinated human erythrocytes and guinea pig peritoneal exudate macrophages. Agglutination of these cell types was inhibited by l-fucose and N-acetyl-d-galactosamine. Human type O erythrocytes removed MIF from FCS. Supernatants of antigen stimulated guinea pig lymphocytes, containing MIF, agglutinated guinea pig peritoneal exudate macrophages which could be inhibited by l-fucose and N-acetyl-d-galactosamine; and human type A erythrocytes which could be inhibited by N-acetyl-d-galactosamine. A macrophage migration stimulatory factor in fetal calf serum (FCS-MIF) was inhibited by N-acetyl-d-galactosamine. These observations suggest that macrophages and erythrocytes have distinct membrane receptors for MIF and MSF and that these receptors contain monosaccharides.

Footnotes

¹ This is Publication 783 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037. The work was supported by United States Public Health Service Grant AI-07007 and Atomic Energy Commission Contract AT(04-3)-779.

² During part of these studies Roy A. Fox was supported by a Medical Research Council (United Kingdom) Travelling Scholarship. Present address: Dalhousie University, Halifax, Nova Scotia, Canada.