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The Journal of Immunology, 1974, 112: 1741-1746.
Copyright © 1974 by The American Association of Immunologists, Inc.
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The Abrogation of Macrophage Migration Inhibition by Pretreatment of Immune Exudate Cells with Anti-{theta} Antibody and Complement

Bruce A. Clinton, Terry J. Magoc and Richard L. Aspinall

From Searle Laboratories, Chicago, Illinois 60680

Abstract

The inhibition of murine (A/J) macrophage migration was not observed after the treatment of the immune exudate cell suspension with AKR anti-{theta} (C3H) antibody. The complement-dependent cytotoxicity of the anti-{theta} could be absorbed with target A/J thymocytes; the resulting absorbed anti-{theta} had no effect on macrophage migration inhibition. There was no cytotoxic effect of the anti-{theta} antibody and complement on IgM and IgG antibody-forming cells as measured by the hemolytic plaque technique.






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