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Antigen Binding T and B Lymphocytes

II. Studies on the Inhibition of Antigen Binding to T and B Cells by anti-Immunoglobulin and anti-H-2 Sera¹

From the Division of Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305

Abstract

The present investigation describes inhibition by anti-Ig and anti-H-2 sera of ¹²⁵I-(T,G)-A--L-binding T and B cells from murine lymph nodes. It was found that T-ABC from unimmunized and immunized mice are partially blocked by anti-IgM sera and not by anti-IgG sera. Furthermore, specific anti-H-2 sera block only T-ABC, but not B-ABC. The possible role of cytophilic IgM in the inhibition of T-ABC by anti-Ig, and the meaning of inhibition by anti-H-2 are discussed.

Footnotes

¹ This research was supported by United States Public Health Service Research Grant AI 07757.

² Recipient of Dernham Fellowship, J-195, from the American Cancer Society, California Division.

³ Senior Investigator of the Arthritis Foundation.

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