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The Journal of Immunology, 1974, 112: 1623-1627.
Copyright © 1974 by The American Association of Immunologists, Inc.

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Glycopeptides of Heavy Chains from Human IgA Myeloma Proteins1

Jean-Pierre J. Despont2 and Carlos A. Abel

From the Section of Allergy and Clinical Immunology, Department of Medicine, National Jewish Hospital and Research Center, Denver, Colorado 80206

Abstract

Glucosamine-containing glycopeptides were isolated from the heavy chains of four human IgA1 and three IgA2 myeloma proteins. The amino acid sequence of two {alpha}1 glycopeptides (1a and 4a) and of three {alpha}2 glycopeptides (1b, 2b, and 3b) isolated from the constant region of {alpha} chains was determined. Peptides 1a and 1 b were localized to the N-terminal half of the Fc fragment, whereas peptides 4a and 3b were localized to the C-terminal half of this fragment.

Footnotes

1 This work was supported by United States Public Health Service, National Institutes of Health Grant AI-09758, and Allergy Disease Center Grant AI-10398.

2 Supported by Fellowships from the Swiss Academy of Medical Sciences and the World Health Organization.




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