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Identification of a Subpopulation of Mouse Lymphoid Cells Required for Interferon Production After Stimulation with Mitogens

From the National Institute of Allergy and Infectious Diseases, Laboratory of Immunology, and Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The cell population necessary for interferon production after mitogen stimulation was investigated in the mouse. Thymus cells and cortisone-resistant thymus cells failed to produce interferon after mitogen stimulation. When spleen cells, a mixture of B and T cells, were treated with anti-K chain serum and complement and then stimulated with PHA, no diminution of interferon production was observed. However, when spleen cells were treated with anti- antibody and complement and then stimulated with PHA, interferon production was markedly reduced. These studies suggest that peripheralized T cells are required for interferon production after mitogen stimulation.

Footnotes

¹ Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20014.

² Present address: Department of Immunology, Mayo Clinic, Rochester, Minnesota 55901. Requests for reprints to be mailed to Dr. Jack Stobo at this address.

³ Laboratory of viral diseases, National Institutes of Health, Bethesda, Maryland 20014.

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