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Comparative in Vitro Studies on Effector Cell Diversity in the Cellular Immune Response to Murine Sarcoma Virus (MSV)-Induced Tumors in Mice¹

From the Laboratoire d'Immunologie des Tumeurs, Institut de Recherches sur les Maladies du Sang, Hópital Saint Louis, 75010 Paris, France

Abstract

The cellular immune response to murine sarcoma virus (MSV)-induced tumors in B6 mice was studied in vitro with two techniques: the ⁵¹Cr release test (CRT) and the microcytotoxicity assay (MA). The analysis of the effector cell nature in each of these assays showed that only thymus-dependent (T) cells are effector cells in CRT, while both T and non-T cells can be effector cells in MA. Comparative studies of the same lymphoid cell preparations demonstrated that the T cells revealed in MA might not be identical with the T cells whose activity is measured in CRT.

Footnotes

¹ This work was supported by contracts from I.N.S.E.R.M. and D.G.R.S.T.