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The Production of Proliferation Inhibitory Factor (PIF) by Mouse Spleen Cells in Vitro¹

From the Departments of Medicine and Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118

Abstract

Concanavalin A and phytohemagglutinin stimulate mouse spleen cells to elaborate proliferation inhibitory factor (PIF) into their culture supernatants. As has been previously described for human PIF, murine PIF is cytostatic in the absence of cytotoxicity and is species-specific. Murine spleen cells, incubated with Escherichia coli lipopolysaccharide, undergo DNA synthesis but do not appear to make PIF.

Footnotes

¹ This work was supported in part by grants from the American Cancer Society (Massachusetts Division), The Damon Runyon Memorial Fund, and Research Grant CA 12209 from the United States Public Health Service.

² Recipient of Career Development Award AI 39,096 from the National Institutes of Health.