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The Journal of Immunology, 1974, 112: 970-978.
Copyright © 1974 by The American Association of Immunologists, Inc.
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Phosphatidylserine Enhancement of Antigen-Induced Mediator Release from Rat Mast Cells1

Daniel J. Stechschulte2 and K. Frank Austen

Department of Medicine, Harvard Medical School and the Robert B. Brigham Hospital, Boston, Massachusetts 02120

Abstract

Phosphatidylserine (PTS) enhances the antigen-induced release of preformed vasoactive amines from rat mast cells both in vivo and in vitro without enhancing the release in vivo of slow reacting substance of anaphylaxis (SRS-A). The duration of mediator release from mast cells is not prolonged by PTS but enhancement is observed when PTS is added before and for as long as 3 min after antigen challenge. PTS enhancement requires intact glycolysis and the presence of calcium ions; it is inhibited by magnesium ions and oligomycin. Antigen-induced release and PTS enhancement are suppressed by agents which increase intracellular levels of cyclic adenosine 3'5'-monophosphate and by the addition of exogenous cyclic AMP in the dibutyryl form.

Footnotes

1 This work was supported by Grant AI-07722 from the National Institutes of Health.

2 Former Recipient of Research Career Development Award 5K04 AI 28,405-02. Present address: Department of Medicine, The University of Kansas Medical Center, Kansas City, Kansas 66103.




This article has been cited by other articles:


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T. Martin and D Lagunoff
Inhibition of mast cell histamine secretion by N-substituteed derivatives of phosphatidylserine
Science, May 11, 1979; 204(4393): 631 - 633.
[Abstract] [PDF]


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