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Autoimmune Murine Thyroiditis

IV. Localization of Genetic Control of the Immune Response¹

Center for Immunology and Department of Microbiology, State University of New York at Buffalo and Department of Human Genetics, The University of Michigan, Ann Arbor, Michigan

Abstract

The immune response to mouse thyroglobulin in mice is associated with the centromeric (left) side of the H-2 region. Thyroid infiltration is strongly controlled by a major gene, probably located between the K-end and the Ir-1 region, but other genes at the D-end of H-2, or outside of the H-2 region, may modify the response. Antibody formation is less strongly influenced by this major gene and may involve additional genetic or non-genetic factors.

Footnotes

¹ This work was supported by Public Health Research Grant CA 02357 from the National Cancer Institute. This is Publication 72 from The Center for Immunology. Portions of this paper were presented at the Annual Meeting of the American Association of Immunologists, Atlantic City, New Jersey, in April, 1973.

² Present address: "Rudjer Boskovic" Institute, Zagreb, Yugoslavia.

³ Present address: Dept. of Immunology & Microbiology, Wayne State University, School of Medicine, Detroit, Mich.

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