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Preparation and Properties of Rabbit Anti-Mouse Plasmacyte Serum Purified by in Vivo Absorption: Further Evidence for a New Antigenic Determinant on Plasmacytes¹

Roswell Park Memorial Institute, ³ Buffalo, New York 14203

Abstract

A new surface antigenic determinant on both normal and malignant plasma cells of mice has been detected with rabbit antisera, obtained by immunization with mouse myeloma cells and purified by in vivo absorption. One IgG- and one IgA-producing myeloma was used. Although the determinant was detected on plasma cells and one lymphoma and not on other lymphoid cells, it was also found on cells of liver, kidney, and brain. Thus the antigen is not a plasmacyte-specific antigen. In spite of an apparent similarity between the tissue representation of the determinant and that of the PC.1 alloantigenic determinant, the present determinant is not identical with the PC.1 determinant, since it is found on the respective tissues of PC.1-negative strains of mice.

Footnotes

¹ This work was supported in part by Grant CA-14562 from the National Cancer Institute.

² On leave of absence from The Institute for Cancer Research, University of Osaka Medical School, Osaka, Japan.

³ A unit of the New York State Department of Health.