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Antibody-Dependent Cell-Mediated Cytotoxicity in Prospective Kidney Transplant Recipients¹

Departments of Biochemistry and Surgery, Wayne State University, School of Medicine, Detroit, Michigan 48201

Abstract

Four types of cytotoxicity were observed in prospective kidney transplant recipients: a) antibody-mediated complement-dependent, b) cell-mediated, c) antibody-dependent cell-mediated (allogeneic effector cells), and d) antibody-dependent cell-mediated (recipient effector cells). The two types of cell-mediated assays which were antibody-dependent could detect the presence of preformed antibodies in recipients when the antibody-mediated complement-dependent cross-match was negative. The use recipient lymphocytes rather than allogeneic lymphocytes as effector cells generally resulted in higher ⁵¹Cr release. This appeared to be the result of antibody present in the recipient plasma directed toward determinants on the allogeneic effector cell. In some instances, however, the higher amount of cell lysis with recipient effector cells did not appear to be due to antibody inhibition of allogeneic effector cells.

Footnotes

¹ This work was supported by grants from the Detroit General Hospital Research Corporation, Michigan Heart Association, Kidney Foundation of Michigan, and by American Cancer Society Grant IC 82.