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The Journal of Immunology, 1974, 112: 877-882.
Copyright © 1974 by The American Association of Immunologists, Inc.
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Rabbit Secretory IgA: Identification and Genetic Control of Two Allotypes of Secretory Component1

Katherine L. Knight2, Miriam Rosenzweig, Edward A. Lichter and W. Carey Hanly

Department of Microbiology and Department of Preventive Medicine and Community Health, University of Illinois, College of Medicine, Chicago, Illinois 60680

Abstract

Two allotypes of rabbit secretory IgA have been identified with antisera obtained by cross-immunization of rabbits with secretory IgA. The two antisera, anti-t61 and anti-t62, each reacted by double diffusion analysis with secretory IgA from some but not all rabbits. Both anti-t61 and anti-t62 reacted with purified free secretory component obtained from whey. Thus, anti-t61 and anti-t62 are identifying allotypic specificities on secretory component.

Genetic studies revealed that t61 and t62 are controlled by allelic genes at an autosomal locus. The t locus is not closely linked to the VHa, C{alpha}f and C{alpha}g (heavy chain) loci nor to the b (light chain) locus of immunoglobulins.

Footnotes

1 This study was supported by Research Grants PHS AI 11234 and PHS AM 11914 from the National Institute of Health.

2 Recipient of National Institutes of Health Research Career Development Award AI 28687.




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