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Allotypes of Rat Immunoglobulins

I. An Allotype at the -Chain Locus¹

Department of Experimental Medicine, University of Louvain, 4, avenue Chapelle-aux-Champs, B-1200 Bruxelles (Belgium)

Abstract

The inheritance and strain distribution of a genetic marker of the -chains of rat IgA, which we propose to call I(1a), was tested by means of a precipitating anti-allotype antiserum obtained by immunizing August rats with a monoclonal IgA protein from a LOU/Wsl rat immunocytoma.

The presence or absence of the I(1a) character appeared to be controlled by a single pair of codominant alleles, which appear to govern the biosynthesis of virtually all the rat serum IgA.

Footnotes

¹ This investigation was supported in part by the F.R.S.M., Brussels, Belgium (Grant 1192) and the "Fonds Cancérologique de la C.G.E.R.," Brussels, Belgium.

² Staff member of EURATOM Biology Division—Publication 918.

³ Supported by a fellowship from the "Fonds Cancérologique de la C.G.E.R." (Belgium).