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The IgM and IgA Immune Response to the TNP Determinant Group in BALB/c Mice¹

From the Department of Medicine, The Jewish Hospital of St. Louis and the Departments of Medicine and Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110

Abstract

These studies document certain features of the splenic IgA plaque-forming cell response and the serum IgA antibody content in BALB/c mice following immunization with TNP-BG. Differences in the magnitude and temporal sequence of the indirect (IgA) and direct (IgM) plaque-forming cell responses have been documented. Following booster immunization, there was a shorter latent period and higher peak level of cells secreting IgA anti-TNP antibodies suggesting an anamnestic response.

Footnotes

¹ This study was supported by Research Grant AI 09723 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, a Research Career Program Award (1-K3-AM-38,620) from the National Institute of Arthritis and Metabolic Diseases, and Research Grant T560 from the American Cancer Society, Inc.