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From the Departments of Microbiology and Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510
Abstract
Cellular immunity of (BALB/c x A)F1 mice has been examined early after induction of a graft-vs-host reaction (GVHR) by (BALB/c) spleen cells. Previous work has shown that such mice develop murine leukemia virus titers early and lymphomas after a latent period of some months. We wished to determine if an impairment of cellular immune capacity could be associated with these phenomena. When GVHR mice were compared to normals in vivo, skin graft rejection was prolonged slightly across the H2 histocompatibility barrier and somewhat more prolonged across a non-H2 barrier, delayed hypersensitivity to tuberculin was slightly reduced, and rejection of two plasmacytoma tumors was more efficient early and normal later in the GVHR. In vitro, lymphocytes from GVHR mice were normal or hyperreactive as indicated by their normal cytotoxicity against cells expressing skin graft antigens and their heightened sensitivity to tuberculin and A9L cells detected as "nonspecific" cytotoxicity. Thus, in the parameters tested there was no evidence of immune suppression at the level of the cell.
Footnotes
1 This work was supported by United States Public Health Service Grant AI-08614 and Subgrant IN-31-L-7 from the American Cancer Society, and The American Heart Association.
2 Supported by a postdoctoral fellowship from the Damon Runyon Memorial Fund for Cancer Research, Inc.
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