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A Rabbit IgG Antigenic Marker Detected by 19S Anti-IgG Present in Streptococcal Antisera¹

From The Rockefeller University, New York, New York 10021

Abstract

19S anti-IgG, produced in rabbits immunized with streptococcal vaccines, was used in a hemagglutination-inhibition test with rabbit IgG-coated erythrocytes for detecting an antigenic marker on rabbit IgG. The 19S anti-IgG in a panel of streptococcal antisera had different agglutinating specificities. An antigenic marker on rabbit IgG-Fc was detected in some but not all normal rabbit sera by the 19S anti-IgG in one of the streptococcal antisera. Detection of this antigenic marker in breeders and their offspring suggested that this antigenic marker was inherited. Further studies are required to determine if it is identical with or distinct from one of the known allotypic markers.

Footnotes

¹ This work was supported by National Institutes of Health Grant AI-08429 and in part by a Grant-in-Aid from the American Heart Association.

² Current address: Sloan-Kettering Institute for Cancer Research, New York, New York 10021.

³ Current address: Scripps Clinic and Research Foundation, La Jolla, California 92037. During the term of this research Dr. Bokisch was supported by a Helen Hay Whitney Foundation fellowship.

⁴ Address: Hospital for Special Surgery and Cornell Medical College, New York, New York 10021.